Hepsera (Adefovir Dipivoxil): Uses, Dosage, Side Effects.

Preparation and characterization of adefovir dipivoxil-stearic acid cocrystal with enhanced physicochemical properties. Seo JW(1), Hwang KM(1), Lee SH(2), Kim DW(2), Park ES(1). Author information: (1)a School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Adefovir dipivoxil undergoes also hydrolysis in aqueous solution and to a smaller degree in the solid state after exposure to humidity and heat for extended periods. Adefovir dipivoxil is synthetised from commercially available starting materials.

Adefovir dipivoxil 3.4 Adefovir is structurally related to the purine base adenine. It is converted intracellularly to the diphosphate, which inhibits the synthesis of hepatitis B virus DNA through competition for the enzyme reverse transcriptase and incorporation into the viral DNA.

The synthesis process comprises the following process routes of: reacting 2-chlorohydrin subjected to cholromethylation and triisopropyl phosphite to generate an adefovir lateral chain which is condensed and hydrolyzed with adenine to generate adefovir, and then carrying out condensation on the adefovir and chloromethyl pivalate to prepare the adefovir dipivoxil product.

Adefovir dipivoxil is an acyclic nucleotide analogue that was developed in part to improve on the limitations of earlier therapies. This article is a review of available data on the clinical.

Adefovir is a prescription medicine used to treat (chronic) infections with hepatitis B virus. A prodrug form of adefovir was previously called bis-POM PMEA, with trade names Preveon and Hepsera.It is an orally administered nucleotide analog reverse-transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil prodrug adefovir dipivoxil. Contents. Uses.

Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.

Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV(3, 4). References: (1).

A series of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) were synthesized and their anti-hepatitis B virus (HBV) activity was evaluated in HepG2 2.2.15 cells, with adefovir dipivoxil as a reference drug.

Adefovir is another nucleoside parallel used in the intervention of lamivudine-resistant CHB entirely or in combination with lamivudine.13 It is an parallel of A which is given at a dosage of 10 milligram daily.4, 13 Adefovir is administered orally as its prodrug, adefovir dipivoxil as it is ill absorbed following unwritten administration.4, 15 Like 3TC, adefovir can besides be used in.

An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.. (CHEBI:31175) has role DNA synthesis inhibitor.

Synthesis of costs and benefits.. These were the virological response rate to adefovir dipivoxil and the virological response rate to lamivudine. If the proportion of the lamivudine arm responding at year 4 increased to above 40.7%, there was a favourable impact on the average cost-effectiveness analysis for the lamivudine strategy.